Structure fire broke out at 914 North 8th Street in Quincy Sunday morning around 9 a.m.
Quincy Fire Department responded to the call and requested four more trucks to help get the smoke under control.
Chief Joe Henning said at this time he doesn't know what caused the fire.
All utilities were off but the abandoned building has been known to catch fire from time to time.
No injuries reported.
Neighbors are not in danger and can remain where they are.
QFD will stay on scene until everything inside the building is under control.
Investigators will be brought in later Sunday.