A semi jackknifed in front of O'Reilly's Auto Parts on the southbound lane of US 61 in Hannibal has been moved.
Crews were finally able to reopen the roadway just before 6 p.m.
Traffic was backed up on McMasters through town for several hours.
The Missouri Department of Transportation still does not recommend travel in most of Missouri. For updated information, call 1-888-275-6636.
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